Antiviral Activities of Silymarin and Derivatives

Ching-Hsuan Liu; Alagie Jassey; Hsin-Ya Hsu; Liang-Tzung Lin

doi:10.3390/molecules24081552

Molecules (Apr 2019)

Antiviral Activities of Silymarin and Derivatives

Ching-Hsuan Liu,
Alagie Jassey,
Hsin-Ya Hsu,
Liang-Tzung Lin

Affiliations

Ching-Hsuan Liu: Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Alagie Jassey: International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Hsin-Ya Hsu: Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Liang-Tzung Lin: Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

DOI: https://doi.org/10.3390/molecules24081552
Journal volume & issue: Vol. 24, no. 8
p. 1552

Abstract

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Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

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