BMJ Open (Aug 2021)
EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry
- Charles B L M Majoie,
- Patrik Michel,
- Marcel Arnold,
- Jan Gralla,
- Urs Fischer,
- Jan F Scheitz,
- Didier Leys,
- Peter Arthur Ringleb,
- Daniel Strbian,
- David J Seiffge,
- George Ntaios,
- Andreas Kastrup,
- Ronen R Leker,
- José E Cohen,
- Nicolas Bricout,
- Alex Brehm,
- Hilde Henon,
- Zsolt Kulcsar,
- Turgut Tatlisumak,
- Alexandros Rentzos,
- Katarina Jood,
- Nicolas Martinez-Majander,
- Alessandro Pezzini,
- Ashraf Eskandari,
- Jan Liman,
- Katharina Feil,
- Lars Kellert,
- Markus Möhlenbruch,
- Georg Bohner,
- Marios Psychogios,
- Mauro Magoni,
- Annika Nordanstig,
- Andrea Zini,
- Henrik Gensicke,
- Sanne M Zinkstok,
- Sami Curtze,
- Christian Hametner,
- Visnja Padjen,
- Susanne Wegener,
- Georg Kägi,
- Christian H Nolte,
- Jan-Erik Karlsson,
- Camilla Karlsson,
- Christopher Traenka,
- Hebun Erdur,
- Johannes Weber,
- Stefan Engelter,
- Gerli Sibolt,
- Philippe Lyrer,
- Merih I Baharoglu,
- Hakan Sarikaya,
- Dejana R Jovanovic,
- Andreas Luft,
- Kimmo Lappalainen,
- John Gomori,
- Ivan Vukasinovic,
- Vladimir Cvetic,
- Eftychia Kapsalaki,
- Paul J J Nederkoorn
Affiliations
- Charles B L M Majoie
- Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- Patrik Michel
- Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Bâtiment Hospitalier Principal, Lausanne, Switzerland
- Marcel Arnold
- Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
- Jan Gralla
- Neuroradiology, Inselspital, University of Bern, Bern, Switzerland
- Urs Fischer
- 3University Hospital Basel, Neurology Clinic, Basel, Switzerland
- Jan F Scheitz
- Department of Neurology with Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany
- Didier Leys
- Neurology, Stroke Unit, CHU Lille, Inserm U1171, Lille, France
- Peter Arthur Ringleb
- Heidelberg University, Heidelberg, Germany
- Daniel Strbian
- Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
- David J Seiffge
- 6 Department of Neurology, Inselspital University Hospital, Bern, Switzerland
- George Ntaios
- 11 Department of Medicine, University of Thessaly, Larissa, Greece
- Andreas Kastrup
- 11 Department of Neurology, Hospital Bremen-Mitte, Bremen, Germany
- Ronen R Leker
- Department of Neurology, Hebrew University Hadassah Medical School, Yerushalayim, Israel
- José E Cohen
- Neurosurgery, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
- Nicolas Bricout
- 11 Department of interventional Neuroradiology, Centre Hospitalier Universitaire de Lille, Lille, France
- Alex Brehm
- 2Diagnostic and Interventional Neuroradiology, University Hospital Basel, Basel, CH
- Hilde Henon
- Department of Vascular Neurology, Lille University Hospital, Lille, France
- Zsolt Kulcsar
- Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland
- Turgut Tatlisumak
- Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
- Alexandros Rentzos
- Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- Katarina Jood
- Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- Nicolas Martinez-Majander
- Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
- Alessandro Pezzini
- Department of Medicine and Surgery, University of Parma, Parma, Italy
- Ashraf Eskandari
- Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
- Jan Liman
- 8 Department of Neurology, University Medicine Goettingen, Goettingen, NS, Germany
- Katharina Feil
- 1 Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany
- Lars Kellert
- 1 Department of Neurology, Ludwig-Maximilians-Universitaet (LMU) Muenchen, Muenchen, Bayern, Germany
- Markus Möhlenbruch
- 14Neuroradiology, Uniklinik Heidelberg, Heidelberg, Germany
- Georg Bohner
- Institute of Neuroradiology, Charité-Universitätsmedizin, Berlin, Germany
- Marios Psychogios
- 1University Hospital Basel, Diagnostic and Interventional Neuroradiology Department, Basel, Switzerland
- Mauro Magoni
- Stroke Unit, Neurologia Vascolare, ASST Spedali Civili di Brescia, Brescia, Italy
- Annika Nordanstig
- Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
- Andrea Zini
- Neurology and Stroke Center, IRCCS Istituto Delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy
- Henrik Gensicke
- Stroke Center and Department of Neurology, University Hospital Basel, Basel, Switzerland
- Sanne M Zinkstok
- Department of Neurology, Amsterdam University Medical Centres, Amsterdam, The Netherlands
- Sami Curtze
- Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
- Christian Hametner
- Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
- Visnja Padjen
- Neurology Clinic, Clinical Centre of Serbia, Belgrade, Clinical Center of Serbia, Beograd, Serbia
- Susanne Wegener
- Department of Neurology, University of Zurich, Zurich, Switzerland
- Georg Kägi
- Department of Neurology, Kantonsspital St Gallen, Sankt Gallen, Switzerland
- Christian H Nolte
- Department of Neurology with Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany
- Jan-Erik Karlsson
- Department of Clinical Neurosciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska Academy, Goteborg, Sweden
- Camilla Karlsson
- Department of Clinical Neurosciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska Academy, Goteborg, Sweden
- Christopher Traenka
- Department of Neurology and Stroke Center, University of Basel and University Hospital Basel, Basel, Switzerland
- Hebun Erdur
- Department of Neurology and Center for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany
- Johannes Weber
- 4 Clinic of Radiology and Nuclear Medicine, Diagnostic and Interventional Neuroradiology, Kantonsspital St Gallen, St. Gallen, Switzerland
- Stefan Engelter
- Department of Neurology and Stroke Center, University of Basel, Basel, Switzerland
- Gerli Sibolt
- Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
- Philippe Lyrer
- Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland
- Merih I Baharoglu
- Department of Neurology, Amsterdam University Medical Centres, Amsterdam, The Netherlands
- Hakan Sarikaya
- Department of Neurology, lnselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- Dejana R Jovanovic
- Neurology Clinic, Clinical Centre of Serbia, Belgrade, Clinical Center of Serbia, Beograd, Serbia
- Andreas Luft
- Department of Neurology, University Hospital Zurich, Zurich, Switzerland
- Kimmo Lappalainen
- Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland
- John Gomori
- Department of Radiology, Hebrew University Hadassah Medical School, Yerushalayim, Israel
- Ivan Vukasinovic
- 8Department of Neuroradiology, Centre for Radiology and Magnetic Resonance Imaging (MRI), University Clinical Center of Serbia, Belgrade, Serbia
- Vladimir Cvetic
- Faculty of Medicine, University of Belgrade, Beograd, Serbia
- Eftychia Kapsalaki
- Department of Radiology, University Hospital of Larissa, School of Medicine, University of Thessaly, Volos, Thessaly, Greece
- Paul J J Nederkoorn
- Department of Neurology, Amsterdam University Medical Centres, Amsterdam, The Netherlands
- DOI
- https://doi.org/10.1136/bmjopen-2020-042211
- Journal volume & issue
-
Vol. 11,
no. 8
Abstract
Purpose The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.Participants All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).Findings to date Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.Future plans This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.
