Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

Ake T. Lu; Eilis Hannon; Morgan E. Levine; Ke Hao; Eileen M. Crimmins; Katie Lunnon; Alexey Kozlenkov; Jonathan Mill; Stella Dracheva; Steve Horvath

doi:10.1038/ncomms10561

Nature Communications (Feb 2016)

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

Ake T. Lu,
Eilis Hannon,
Morgan E. Levine,
Ke Hao,
Eileen M. Crimmins,
Katie Lunnon,
Alexey Kozlenkov,
Jonathan Mill,
Stella Dracheva,
Steve Horvath

Affiliations

Ake T. Lu: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
Eilis Hannon: University of Exeter Medical School, University of Exeter
Morgan E. Levine: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
Ke Hao: Department of Genetics and Genomic Sciences, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Eileen M. Crimmins: Davis School of Gerontology, University of Southern California, Ethel Percy Andrus Gerontology Center
Katie Lunnon: University of Exeter Medical School, University of Exeter
Alexey Kozlenkov: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Jonathan Mill: University of Exeter Medical School, University of Exeter
Stella Dracheva: Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Steve Horvath: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles

DOI: https://doi.org/10.1038/ncomms10561
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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This genome-wide association study identifies five significant SNPs in two loci which are associated with the epigenetic age of post-mortem cerebellar tissue according to a DNA methylation based biomarker of human aging.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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