Frontiers in Immunology (Mar 2012)
Autophagosomal protein dynamics and influenza virus infection
Abstract
Autophagy is a constitutive, catabolic process leading to the lysosomal degradation of cytosolic proteins and organelles. However, it is also induced under stress conditions, remodeling the eukaryotic cell by regulating energy, protein and lipid homeostasis. It is likely that the autophagosomal/lysosomal pathway evolved primordially to recycle cell components, but further functionally developed as to become part of the immune system to defend against invading pathogens. Likewise, pathogenic, foreign agents developed strategies to fight back and even to employ the autophagy machinery to their own benefit. Hence, the regulation of autophagy has many implications on human health and disease. This review summarizes the molecular dynamics of autophagosome formation, maturation and target selection. Membrane dynamics, as well as protein-protein and protein-membrane interactions are particularly addressed. In addition, it recapitulates current knowledge of the influences of influenza virus infection on the process.
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