NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway

Hao Zhang; Zhaoyuan Chen; Ji’an Zhou; Jiahui Gu; Han Wu; Yi Jiang; Shenjia Gao; Yun Liao; Rulin Shen; Changhong Miao; Wankun Chen

doi:10.1038/s42003-022-03868-x

Communications Biology (Sep 2022)

NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway

Hao Zhang,
Zhaoyuan Chen,
Ji’an Zhou,
Jiahui Gu,
Han Wu,
Yi Jiang,
Shenjia Gao,
Yun Liao,
Rulin Shen,
Changhong Miao,
Wankun Chen

Affiliations

Hao Zhang: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Zhaoyuan Chen: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Ji’an Zhou: Department of Respiratory and Critical Care Medicine, Huadong Hospital Affiliated to Fudan University
Jiahui Gu: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Han Wu: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Yi Jiang: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Shenjia Gao: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Yun Liao: Shanghai Medical College of Fudan University
Rulin Shen: Shanghai Laboratory Animal Research Center
Changhong Miao: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University
Wankun Chen: Department of Anesthesiology, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University

DOI: https://doi.org/10.1038/s42003-022-03868-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The enzyme N-acetyltransferase NAT10 is a negative regulator of neutrophil pyroptosis and its downregulation contributes to the progress of sepsis by exacerbating pyroptosis via the ULK1-STING-NLRP3 pathway.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal