Classification of Alzheimer’s Disease Based on Core-Large Scale Brain Network Using Multilayer Extreme Learning Machine

Abstract

Various studies suggest that the network deficit in default network mode (DMN) is prevalent in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Besides DMN, some studies reveal that network alteration occurs in salience network motor networks and large scale network. In this study we performed classification of AD and MCI from healthy control considering the network alterations in large scale network and DMN. Thus, we constructed the brain network from functional magnetic resonance (fMR) images. Pearson’s correlation-based functional connectivity was used to construct the brain network. Graph features of the brain network were converted to feature vectors using Node2vec graph-embedding technique. Two classifiers, single layered extreme learning and multilayered extreme learning machine, were used for the classification together with feature selection approaches. We performed the classification test on the brain network of different sizes including the large scale brain network, the whole brain network and the combined brain network. Experimental results showed that the least absolute shrinkage and selection operator (LASSO) feature selection method generates better classification accuracy on large network size, and that feature selection with adaptive structure learning (FSAL) feature selection technique generates better classification accuracy on small network size.

Keywords

• Alzheimer’s disease
• large-scale brain network
• extreme learning machine