Green synthesis of silver nanoparticle using goniothalamus wightii on graphene oxide nanocomposite for effective voltammetric determination of metronidazole

Abstract

Graphene oxide (GO) has piqued the interest of both academia and industry owing to its polar and two-dimensional (2D) layered structure. Antibiotic concentrations can be detected with advanced GO composites to reduce the risk of bacterial resistance, which can be done with electrochemical sensors. Herein, we have developed an eco-friendly synthesis approach, one-pot strategy towards Goniothalamus wightii biomass-derived solution preparation of Ag nanoparticle-decorated graphene oxide (GO@AgNPs) composites. As- synthesized GO@AgNPs nanocomposites were analyzed using various analytical tools including Raman, X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM). The Metronidazole (MIZ) determination was then investigated using cycle volumetric and amperometric (i-t) techniques by the GO@AgNPs composites. Prepared composites exhibit a wide-linear range of 0.09 μM to 4.594 mM, low detection limit of 69 nM and a limit of quantification detection of 786 nM. Furthermore, the practical applicability of the prepared GO@AgNPs nanocomposites were examined in pharmaceutical drug Flagyl (500 mg) with satisfactory recovery results.

Keywords

• Green synthesis
• AgNPs
• GO@AgNPs composite
• Metronidazole
• electrochemical sensor