Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

Wen Hao Neo; Yiran Meng; Alba Rodriguez-Meira; Muhammad Z. H. Fadlullah; Christopher A. G. Booth; Emanuele Azzoni; Supat Thongjuea; Marella F. T. R. de Bruijn; Sten Eirik W. Jacobsen; Adam J. Mead; Georges Lacaud

doi:10.1038/s41467-021-27140-8

Nature Communications (Dec 2021)

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

Wen Hao Neo,
Yiran Meng,
Alba Rodriguez-Meira,
Muhammad Z. H. Fadlullah,
Christopher A. G. Booth,
Emanuele Azzoni,
Supat Thongjuea,
Marella F. T. R. de Bruijn,
Sten Eirik W. Jacobsen,
Adam J. Mead,
Georges Lacaud

Affiliations

Wen Hao Neo: Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Yiran Meng: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Alba Rodriguez-Meira: Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Muhammad Z. H. Fadlullah: Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester
Christopher A. G. Booth: Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Emanuele Azzoni: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Supat Thongjuea: MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Marella F. T. R. de Bruijn: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Sten Eirik W. Jacobsen: Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Adam J. Mead: Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Georges Lacaud: Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/s41467-021-27140-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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