Assessment of Triglyceride/Glucose Index as a Predictor of Insulin Resistance in Comparison with Homeostasis Model Assessment for Insulin Resistance (HOMA-IR): in a Referral Laboratory

Abstract

Objective: To investigate triglyceride glucose index (TyG index) as a predictor of insulin resistance (IR) in comparison with homeostasis model assessment for insulin resistance (HOMA-IR) for the screening of DM in healthy adult population Study Design: Cross-sectional comparative study. Place and Duration of Study: The study was done at Chemical Pathology & Endocrinology Department, Armed Forces Institute of Pathology, Rawalpindi from 01st June 2022 to 31st May 2023 over a period of one year. Materials and Methods: The study comprised 307 healthy individuals coming for laboratory investigations to our laboratory after routine annual checkup at Combine Military Hospital, Rawalpindi. Individuals of both genders aged between 18 and 35 years were included and initial history of any previous medical condition was taken. All the participants with previous history of any chronic disease were excluded. Healthy individuals who were disease free were included. Blood sample was taken in clot activator and sodium fluoride tube for lipid profile, serum insulin fasting and blood glucose fasting, respectively. Formula used for estimation of HOMA-IR was: The equation used for TyG index was natural log of fasting plasma glucose and triglycerides divided by 2 i.e. .... Results: A comparative analysis was done using SPSS version 29.0 and revealing a significant positive correlation between the TyG index and HOMA-IR with an r value of 0.79 and p value = 0.001 where p value <0.01 is considered as significant. Conclusion: TyG index can be used as a surrogate marker of HOMA-IR to predict insulin resistance in healthy adults population.

Keywords

• diabetes mellitus
• homa-ir
• insulin resistance
• metabolic syndrome
• tyg index.