Nature Communications (Aug 2018)

Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

  • Peixin Song,
  • Nan Zheng,
  • Yong Liu,
  • Chen Tian,
  • Xilin Wu,
  • Xiaohua Ma,
  • Deyan Chen,
  • Xue Zou,
  • Guiyang Wang,
  • Huanru Wang,
  • Yongyang Zhang,
  • Sufang Lu,
  • Chao Wu,
  • Zhiwei Wu

DOI
https://doi.org/10.1038/s41467-018-05746-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.