The Efficacy of Eradication of Helicobacter pylori Infection in Primary Prevention of NSAID-induced Gastropathy

Abstract

With the aim of clarifying the efficacy of eradication therapy for Helicobacter pylori (Hp) infection in primary prevention of NSAID-induced gastropathy, we have examined 39 Hp-positive patients, in whom we planned to administer non-steroidal anti-inflammatory drugs (NSAIDs) for various arthritis. In group I, non-steroidal anti-inflammatory drugs were prescribed after anti-helicobacter therapy, in group II eradication was not carried out, and the patients immediately received diclofenac. In both groups the incidence of peptic ulcers has been compared in 1 month after receiving diclofenac. In group I, peptic ulcers occurred in 2 patients (10.5 %), in group II — in 5 patients (26.3 %), ie in the group of eradication therapy they occurred significantly less frequently (χ2 = 0.5221). It is concluded that eradication of Hp-infection can be considered as an effective strategy for primary prevention of NSAID-induced gastropathy.

Keywords

• NSAID-induced gastropathy
• eradication of Helicobacter pylori infection