Anti-nociceptive effects of the aqueous extracts of Portulaca Oleracea seeds in mice

Abstract

Background and objective: Portulaca oleracea (PO) overgrows in the different parts of Iran, that is used there as both a salad green and a medicinal plant. In previous studies, a 10% ethanolic extracts of the aerial parts (Leaf and stem) of PO showed anti-nociceptive activity in mice and rats. This study was designed to evaluate anti-nociceptive effects of different doses of the aqueous decoction extracts of PO (Seed). Methods: In this study, 65 male mice (25-30 gr) in model tail flick were used. Different doses of the extract 25, 50, 75, 100 mg/kg (IP) were injected to the separated groups of four (Test group) and water (10 ml/kg-IP) was injected to the one control group. The anti-nociceptive effect was determined 15 and 30 min after injection (N=15 mice for pilot study). Findings: The results showed that there was a significant difference between two groups (P<0.05), but the animals of test groups did not show significant difference in different doses and time. Conclusion: It is concluded that the aqueous extract of PO has anti-nociceptive activity, which is not related to dose and time.

Keywords

• portulaca oleracea (seed)
• anti-nociception
• tail flick