Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

Chao Wu; Yanqin Bian; Bingjie Lu; Dan Wang; Nisma Lena Bahaji Azami; Gang Wei; Feng Ma; Mingyu Sun

doi:10.1186/s12967-022-03495-4

Journal of Translational Medicine (Jun 2022)

Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

Chao Wu,
Yanqin Bian,
Bingjie Lu,
Dan Wang,
Nisma Lena Bahaji Azami,
Gang Wei,
Feng Ma,
Mingyu Sun

Affiliations

Chao Wu: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Yanqin Bian: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Bingjie Lu: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Dan Wang: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Nisma Lena Bahaji Azami: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Gang Wei: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Human Phenome Institute, Fudan University
Feng Ma: Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College
Mingyu Sun: Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine

DOI: https://doi.org/10.1186/s12967-022-03495-4
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 13

Abstract

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Highlights 1. Diacerein/rhein as NLRP3 blockers used in treating osteoarthritis clinically. 2. RFAs including rhein/diacerein are main components of Rhubarb contained in yinchenhao decoction. 3. RFAs inhibited the transcription and assembly of NLRP3 inflammasome. 4. RFAs, Rhubarb and yinchenhao decoction improved NAFLD probably by inhibiting NLRP3 inflammasome. 5. RFAs are the potential NLRP3 inflammasome blockers for treating NAFLD clinically.

Published in Journal of Translational Medicine

ISSN: 1479-5876 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://translational-medicine.biomedcentral.com/

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Abstract

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