Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

• Toni T. Lemmetyinen,
• Emma W. Viitala,
• Linnea Wartiovaara,
• Tuomas Kaprio,
• Jaana Hagström,
• Caj Haglund,
• Pekka Katajisto,
• Timothy C. Wang,
• Eva Domènech-Moreno,
• Saara Ollila

Affiliations

Toni T. Lemmetyinen

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Emma W. Viitala

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Linnea Wartiovaara

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Tuomas Kaprio

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Jaana Hagström

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Caj Haglund

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland

Pekka Katajisto

Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland

Timothy C. Wang

Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA

Eva Domènech-Moreno

HiLIFE-Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland

Saara Ollila

Translational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland