Nature Communications (Jan 2017)
The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
- Krishnendu Chakraborty,
- Mahesh Raundhal,
- Bill B. Chen,
- Christina Morse,
- Yulia Y. Tyurina,
- Anupriya Khare,
- Timothy B. Oriss,
- Rachael Huff,
- Janet S. Lee,
- Claudette M. St. Croix,
- Simon Watkins,
- Rama K. Mallampalli,
- Valerian E. Kagan,
- Anuradha Ray,
- Prabir Ray
Affiliations
- Krishnendu Chakraborty
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Mahesh Raundhal
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Bill B. Chen
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Christina Morse
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Yulia Y. Tyurina
- Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh School of Medicine
- Anupriya Khare
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Timothy B. Oriss
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Rachael Huff
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Janet S. Lee
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Claudette M. St. Croix
- Center for Biologic Imaging, University of Pittsburgh School of Medicine, 3500 Terrace St
- Simon Watkins
- Center for Biologic Imaging, University of Pittsburgh School of Medicine, 3500 Terrace St
- Rama K. Mallampalli
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Valerian E. Kagan
- Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh School of Medicine
- Anuradha Ray
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- Prabir Ray
- Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine
- DOI
- https://doi.org/10.1038/ncomms13944
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Non-resolving bacterial pneumonia results in lung tissue damage owing to overactive inflammation. Here the authors show that the mitochondrial DAMP cardiolipin contributes to persistent inflammation by SUMOylating PPARγ, which promotes binding of the corepressor NCOR/HDAC3 complex to the IL-10 promoter.
