Nature Communications (Apr 2021)
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses
- Nicoletta Caronni,
- Giulia Maria Piperno,
- Francesca Simoncello,
- Oriana Romano,
- Simone Vodret,
- Yuichi Yanagihashi,
- Regine Dress,
- Charles-Antoine Dutertre,
- Mattia Bugatti,
- Pierre Bourdeley,
- Annalisa Del Prete,
- Tiziana Schioppa,
- Emilia Maria Cristina Mazza,
- Licio Collavin,
- Serena Zacchigna,
- Renato Ostuni,
- Pierre Guermonprez,
- William Vermi,
- Florent Ginhoux,
- Silvio Bicciato,
- Shigekatzu Nagata,
- Federica Benvenuti
Affiliations
- Nicoletta Caronni
- Department of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, ICGEB
- Giulia Maria Piperno
- Department of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, ICGEB
- Francesca Simoncello
- Department of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, ICGEB
- Oriana Romano
- Department of Life Sciences, University of Modena and Reggio Emilia
- Simone Vodret
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Yuichi Yanagihashi
- Laboratory of Biochemistry & Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University
- Regine Dress
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Charles-Antoine Dutertre
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Mattia Bugatti
- Department of Molecular and Translational Medicine, School of Medicine, University of Brescia
- Pierre Bourdeley
- Centre for Inflammation Biology and Cancer Immunology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London
- Annalisa Del Prete
- Department of Molecular and Translational Medicine, University of Brescia
- Tiziana Schioppa
- Department of Molecular and Translational Medicine, University of Brescia
- Emilia Maria Cristina Mazza
- Department of Life Sciences, University of Modena and Reggio Emilia
- Licio Collavin
- Department of Life Sciences (DSV), University of Trieste
- Serena Zacchigna
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Renato Ostuni
- San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute
- Pierre Guermonprez
- Centre for Inflammation Biology and Cancer Immunology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London
- William Vermi
- Department of Molecular and Translational Medicine, School of Medicine, University of Brescia
- Florent Ginhoux
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Silvio Bicciato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Shigekatzu Nagata
- Laboratory of Biochemistry & Immunology, World Premier International Research Center, Immunology Frontier Research Center, Osaka University
- Federica Benvenuti
- Department of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, ICGEB
- DOI
- https://doi.org/10.1038/s41467-021-22535-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.
