Nature Communications (Jun 2021)

Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations

  • Nicholas C. Cullen,
  • Antoine Leuzy,
  • Shorena Janelidze,
  • Sebastian Palmqvist,
  • Anna L. Svenningsson,
  • Erik Stomrud,
  • Jeffrey L. Dage,
  • Niklas Mattsson-Carlgren,
  • Oskar Hansson

DOI
https://doi.org/10.1038/s41467-021-23746-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Plasma biomarkers of amyloid, tau and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. Here, the authors show plasma ATN biomarkers predict clinical deterioration and cognitive decline and show in a simulated clinical trial combining all three biomarkers reduced the required sample size.