Modern approaches to studying the antimicrobial and antifungal activities of new 1,2,4-triazole derivatives

Abstract

1,2,4-Triazole and its derivatives are a promising class of organic compounds. For a long time, they remain in the spotlight due to a number of unique properties: high ability to chemical transformations, the presence of various types of biological activity and, of course, low toxicity. Also, a number of 1,2,4-triazole derivatives are currently well studied and implemented in various spheres of human life as effective drugs, various plant protection products (growth stimulants, fungicides, herbicides), anti-corrosion materials, plasticizers, etc. The aim of the work was to analyze and systematize new data on antimicrobial and antifungal activity of 1,2,4-triazole derivatives and to select a promising area of ​​research based on the accumulation of a large amount of information on the properties of new 1,2,4-triazole derivatives. The analysis of modern sources of information in recent years argues and proves the prospects for finding new biologically active compounds in a number of 1,2,4-triazole derivatives. The information obtained clearly indicates the possibility of using 1,2,4-triazoles, which contain a Sulfur atom, as objects of study. 1,2,4-Triazole is one of the most well-known classes of biologically active compounds, which has a wide range of biological action. Derivatives of 1,2,4-triazole are characterized by the presence of antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, antitumor, antiviral activities. The trend of creating new effective drugs based on 1,2,4-triazole derivatives is growing. Some of the drugs are 1,2,4-triazole derivatives: ribavirin (an antiviral agent), risatriptan (a selective 5HT1 serotonin receptor agonist), alprazolam (an anxiolytic agent), fluconazole, and itraconazole (antifungal drugs). Derivatives of this compound have proven themselves well in veterinary medicine. Drugs such as Avesstim, Trifuzol, Trifuzol-neo are immunostimulants and in various dosage forms (1%, 2% solutions, suppositories) are used in veterinary farms, in the private livestock sector and for pets. These facts are the best example for understanding the prospects of finding new molecules among 1,2,4-triazole derivatives.

Keywords

• organic compounds
• 1
• 2
• 4-triazole
• derivatives
• antimicrobial activity
• antifungal activity