Research Progress of Sirtuin4 in Cancer

Yibing Bai; Yibing Bai; Jiani Yang; Jiani Yang; Ying Cui; Ying Cui; Yuanfei Yao; Yuanfei Yao; Feng Wu; Caiqi Liu; Xiaona Fan; Yanqiao Zhang; Yanqiao Zhang

doi:10.3389/fonc.2020.562950

Frontiers in Oncology (Jan 2021)

Research Progress of Sirtuin4 in Cancer

Yibing Bai,
Yibing Bai,
Jiani Yang,
Jiani Yang,
Ying Cui,
Ying Cui,
Yuanfei Yao,
Yuanfei Yao,
Feng Wu,
Caiqi Liu,
Xiaona Fan,
Yanqiao Zhang,
Yanqiao Zhang

Affiliations

Yibing Bai: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Yibing Bai: Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China
Jiani Yang: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Jiani Yang: Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China
Ying Cui: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Ying Cui: Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Yuanfei Yao: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Yuanfei Yao: Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China
Feng Wu: Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Caiqi Liu: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Xiaona Fan: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Yanqiao Zhang: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
Yanqiao Zhang: Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China

DOI: https://doi.org/10.3389/fonc.2020.562950
Journal volume & issue: Vol. 10

Abstract

Read online

Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords