This work aimed to study the intensification of flow boiling heat transfer and critical heat flux (CHF) under conditions of highly reduced pressures due to a modification of the inner wall surface of a mini-channel. Such research is relevant to the growing need of high-tech industries in the development of compact and energy-efficient heat exchange devices. We present experimental results of the surface modification effect on hydrodynamics and flow boiling heat transfer, including data on the CHF. A description of the experimental stand and method for modifying the test mini-channel is also presented. The studies were carried out with freon R-125 in a vertical mini-channel with a diameter of 1.1 mm and a length of 50 mm, in the range of mass flow rates from G = 200 to 1400 kg/(m2s) and reduced pressures between pr = p/pcr = 0.43 and 0.56. The maximum surface modification effect was achieved at a reduced pressure of pr = 0.43, the heat transfer coefficient increased up to 110%, and the CHF increased up to 22%.