Frontiers in Human Neuroscience (Aug 2021)
Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study
- Jia Tuo,
- Jia Tuo,
- Jia Tuo,
- Wei He,
- Wei He,
- Wei He,
- Shuai Yang,
- Shuai Yang,
- Lihui Liu,
- Lihui Liu,
- Lihui Liu,
- Xiaojuan Liu,
- Xiaojuan Liu,
- Xiaojuan Liu,
- Hui Liu,
- Hui Liu,
- Yang Wang,
- Yang Wang,
- Yang Wang,
- Tao Tang,
- Tao Tang,
- Tao Tang,
- Jian Xia,
- Jian Xia,
- Jian Xia,
- Weihua Liao,
- Weihua Liao,
- Weihua Liao,
- Yunhai Liu,
- Yunhai Liu,
- Yunhai Liu,
- Qing Huang,
- Qing Huang,
- Qing Huang
Affiliations
- Jia Tuo
- Department of Neurology, Chenzhou No.1 People's Hospital, Chenzhou, China
- Jia Tuo
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Jia Tuo
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Wei He
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Wei He
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Wei He
- Department of Emergency, Xiangya Hospital, Central South University, Changsha, China
- Shuai Yang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Shuai Yang
- Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
- Lihui Liu
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Lihui Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Lihui Liu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Xiaojuan Liu
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Xiaojuan Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Xiaojuan Liu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Hui Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Hui Liu
- Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
- Yang Wang
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Yang Wang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yang Wang
- Department of Integrated Traditional and Western, Xiangya Hospital, Central South University, Changsha, China
- Tao Tang
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Tao Tang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Tao Tang
- Department of Integrated Traditional and Western, Xiangya Hospital, Central South University, Changsha, China
- Jian Xia
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Jian Xia
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jian Xia
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Weihua Liao
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Weihua Liao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Weihua Liao
- Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
- Yunhai Liu
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Yunhai Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yunhai Liu
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- Qing Huang
- Hunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, China
- Qing Huang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Qing Huang
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fnhum.2021.685763
- Journal volume & issue
-
Vol. 15
Abstract
Purpose: Previous studies have found that there are significant changes in functional network properties for patients with moderate to severe carotid artery stenosis. Our study aimed to explore the topology properties of brain functional network in asymptomatic patients with carotid plaque without significant stenosis.Methods: A total of 61 asymptomatic patients with carotid plaque (mean age 61.79 ± 7.35 years) and 25 healthy control subjects (HC; 58.12 ± 6.79 years) were recruited. General data collection, carotid ultrasound examination and resting state functional magnetic resonance imaging were performed on all subjects. Graph-theory was applied to examine the differences in the brain functional network topological properties between two groups.Results: In the plaque group, Eloc(P = 0.03), γ (P = 0.01), and σ (P = 0.01) were significantly higher than in the HC group. The degree centrality of left middle frontal gyrus and the nodal efficiency of left middle frontal gyrus and right inferior parietal angular gyrus were significantly higher in the plaque group than in HC. The degree centrality and betweenness centrality of right middle temporal gyrus, as well as the nodal efficiency of right middle temporal gyrus, were significantly lower in the plaque group than in HC.Conclusions: The brain functional networks of patients with carotid plaques differ from those of healthy controls. Asymptomatic patients with carotid plaques exhibit increased local and global connectivity, which may reflect subtle reorganizations in response to early brain damage.
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