Infection and Drug Resistance (Apr 2022)
The Epidemiological, Clinical Features and Outcomes of Imported Chinese COVID-19 Patients Following Inactivated Vaccines Injection
Abstract
Jianwu Li,1,2,* Na Jiang,1,2,* Qing-Lei Zeng,3,* Yue Zhang,4 Xinyuan He,4 Yao Chu,1,2 Wenni Jin,1,2 Yi Liu,4 Wan Shi,1,2 Miao Yang,1,2 Weihan He,1,2 Qing Han,5 Le Ma,4 You Xu,1,2 Yaling Guo,1,2 Lei Zhang,6– 9 Fanpu Ji2,4,10,11 1Isolation Ward for Covid-19, the Eighth Hospital of Xi’an City, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Shaanxi Provincial Clinical Medical Research Center of Infectious Diseases, Xi’an, Shaanxi, People’s Republic of China; 3Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 4Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 5Department of Integrated Traditional Chinese and Western Medicine, the Eighth Hospital of Xi’an City, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 6China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science Centre, Xi’an, Shaanxi, People’s Republic of China; 7Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia; 8Central Clinical School, Faculty of Medicine, Monash University, Melbourne, Australia; 9Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 10National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 11Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education of China, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanpu Ji, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China, Tel/Fax +862987678223, Email [email protected] Yaling Guo, Isolation ward for COVID-19, the Eighth Hospital of Xi’an City, Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, People’s Republic of China, Tel/Fax +8629 85230200, Email [email protected]: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination had been demonstrated as an effective way to reduce the risk of coronavirus disease 2019 (COVID-19), and only a few vaccines suffered from SARS-CoV-2 infection. However, limited data concerning the clinical features of these vaccines infected with SARS-CoV-2 can be identified.Methods: We retrospectively collected and analyzed epidemiological and clinical characteristics data of the imported COVID-19 cases who received Chinese inactivated vaccines abroad. Data were extracted from electronic medical records from a designated hospital in the Shaanxi Province of China between March 22 and May 17, 2021.Results: Totally, 46 confirmed SARS-CoV-2 infection patients were enrolled. The mean age was 40.5 years (range 20– 61), 41 (89.1%) are male. Eighteen (39.1%) patients were from Pakistan. Fourteen (30.4%) patients had at least one comorbidity. Forty (87.0%) and 6 cases were fully vaccinated and partly vaccinated. The time interval between vaccination and infection was 88 days (IQR, 33– 123), 31 (67.4%) and 15 (32.6%) were asymptomatic and symptomatic cases, respectively. Fever (3/46, 6.5%) was the most common symptom; however, none had a body temperature higher than 38.0°C, and no severe case was observed. Notably, the rate of SARS-CoV-2 shedding discontinuation at 7 days after hospitalization in asymptomatic cases was higher than symptomatic one (93.5% vs 40%, P < 0.0001).Conclusion: Individuals who received Chinese inactivated vaccines abroad remain to have the probability of being infected with SARS-CoV-2, but all the vaccines infected with SARS-CoV-2 were asymptomatic or had mild symptoms with favorable clinical outcomes.Keywords: SARS-CoV-2, COVID-19, vaccination, reinfection, asymptomatic infection
