DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers

Abstract

In this work, the authors show that α-synuclein is posttranslationally dopanized at Tyr136 by tyrosine hydroxylase, which facilitates the formation of oligomers. This modification likely impacts pathogenesis and the selective degeneration of dopaminergic neurons in Parkinson’s disease.