Nature Communications (Aug 2021)
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
- Alexander Bolaender,
- Danuta Zatorska,
- Huazhong He,
- Suhasini Joshi,
- Sahil Sharma,
- Chander S. Digwal,
- Hardik J. Patel,
- Weilin Sun,
- Brandon S. Imber,
- Stefan O. Ochiana,
- Maulik R. Patel,
- Liza Shrestha,
- Smit. K. Shah,
- Shuo Wang,
- Rashad Karimov,
- Hui Tao,
- Pallav D. Patel,
- Ananda Rodilla Martin,
- Pengrong Yan,
- Palak Panchal,
- Justina Almodovar,
- Adriana Corben,
- Andreas Rimner,
- Stephen D. Ginsberg,
- Serge Lyashchenko,
- Eva Burnazi,
- Anson Ku,
- Teja Kalidindi,
- Sang Gyu Lee,
- Milan Grkovski,
- Bradley J. Beattie,
- Pat Zanzonico,
- Jason S. Lewis,
- Steve Larson,
- Anna Rodina,
- Nagavarakishore Pillarsetty,
- Viviane Tabar,
- Mark P. Dunphy,
- Tony Taldone,
- Fumiko Shimizu,
- Gabriela Chiosis
Affiliations
- Alexander Bolaender
- Program in Chemical Biology, Sloan Kettering Institute
- Danuta Zatorska
- Program in Chemical Biology, Sloan Kettering Institute
- Huazhong He
- Program in Chemical Biology, Sloan Kettering Institute
- Suhasini Joshi
- Program in Chemical Biology, Sloan Kettering Institute
- Sahil Sharma
- Program in Chemical Biology, Sloan Kettering Institute
- Chander S. Digwal
- Program in Chemical Biology, Sloan Kettering Institute
- Hardik J. Patel
- Program in Chemical Biology, Sloan Kettering Institute
- Weilin Sun
- Program in Chemical Biology, Sloan Kettering Institute
- Brandon S. Imber
- Program in Chemical Biology, Sloan Kettering Institute
- Stefan O. Ochiana
- Program in Chemical Biology, Sloan Kettering Institute
- Maulik R. Patel
- Program in Chemical Biology, Sloan Kettering Institute
- Liza Shrestha
- Program in Chemical Biology, Sloan Kettering Institute
- Smit. K. Shah
- Program in Chemical Biology, Sloan Kettering Institute
- Shuo Wang
- Program in Chemical Biology, Sloan Kettering Institute
- Rashad Karimov
- Program in Chemical Biology, Sloan Kettering Institute
- Hui Tao
- Program in Chemical Biology, Sloan Kettering Institute
- Pallav D. Patel
- Program in Chemical Biology, Sloan Kettering Institute
- Ananda Rodilla Martin
- Program in Chemical Biology, Sloan Kettering Institute
- Pengrong Yan
- Program in Chemical Biology, Sloan Kettering Institute
- Palak Panchal
- Program in Chemical Biology, Sloan Kettering Institute
- Justina Almodovar
- Program in Chemical Biology, Sloan Kettering Institute
- Adriana Corben
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Andreas Rimner
- Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center
- Stephen D. Ginsberg
- Center for Dementia Research, Nathan Kline Institute
- Serge Lyashchenko
- Radiochemistry and Molecular Imaging Probes Core, Sloan Kettering Institute
- Eva Burnazi
- Radiochemistry and Molecular Imaging Probes Core, Sloan Kettering Institute
- Anson Ku
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Teja Kalidindi
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Sang Gyu Lee
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Milan Grkovski
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center
- Bradley J. Beattie
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center
- Pat Zanzonico
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center
- Jason S. Lewis
- Radiochemistry and Molecular Imaging Probes Core, Sloan Kettering Institute
- Steve Larson
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Anna Rodina
- Program in Chemical Biology, Sloan Kettering Institute
- Nagavarakishore Pillarsetty
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Viviane Tabar
- Department of Neurosurgery, Memorial Sloan Kettering Cancer Center
- Mark P. Dunphy
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Tony Taldone
- Program in Chemical Biology, Sloan Kettering Institute
- Fumiko Shimizu
- Program in Chemical Biology, Sloan Kettering Institute
- Gabriela Chiosis
- Program in Chemical Biology, Sloan Kettering Institute
- DOI
- https://doi.org/10.1038/s41467-021-24821-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studies in Alzheimer’s disease and cancer.
