Nature Communications (Jun 2021)
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech
- Keith A. Josephs,
- Joseph R. Duffy,
- Heather M. Clark,
- Rene L. Utianski,
- Edythe A. Strand,
- Mary M. Machulda,
- Hugo Botha,
- Peter R. Martin,
- Nha Trang Thu Pham,
- Julie Stierwalt,
- Farwa Ali,
- Marina Buciuc,
- Matthew Baker,
- Cristhoper H. Fernandez De Castro,
- Anthony J. Spychalla,
- Christopher G. Schwarz,
- Robert I. Reid,
- Matthew L. Senjem,
- Clifford R. Jack,
- Val J. Lowe,
- Eileen H. Bigio,
- Ross R. Reichard,
- Eric. J. Polley,
- Nilufer Ertekin-Taner,
- Rosa Rademakers,
- Michael A. DeTure,
- Owen A. Ross,
- Dennis W. Dickson,
- Jennifer L. Whitwell
Affiliations
- Keith A. Josephs
- Department of Neurology, Mayo Clinic
- Joseph R. Duffy
- Department of Neurology, Mayo Clinic
- Heather M. Clark
- Department of Neurology, Mayo Clinic
- Rene L. Utianski
- Department of Neurology, Mayo Clinic
- Edythe A. Strand
- Department of Neurology, Mayo Clinic
- Mary M. Machulda
- Department of Psychiatry and Psychology, Mayo Clinic
- Hugo Botha
- Department of Neurology, Mayo Clinic
- Peter R. Martin
- Department of Quantitative Health Sciences (Biostatistics), Mayo Clinic
- Nha Trang Thu Pham
- Department of Radiology, Mayo Clinic
- Julie Stierwalt
- Department of Neurology, Mayo Clinic
- Farwa Ali
- Department of Neurology, Mayo Clinic
- Marina Buciuc
- Department of Neurology, Mayo Clinic
- Matthew Baker
- Department of Neuroscience
- Cristhoper H. Fernandez De Castro
- Department of Neuroscience
- Anthony J. Spychalla
- Department of Radiology, Mayo Clinic
- Christopher G. Schwarz
- Department of Radiology, Mayo Clinic
- Robert I. Reid
- Department of Information Technology
- Matthew L. Senjem
- Department of Radiology, Mayo Clinic
- Clifford R. Jack
- Department of Radiology, Mayo Clinic
- Val J. Lowe
- Department of Radiology, Mayo Clinic
- Eileen H. Bigio
- Department of Pathology, Northwestern University School of Medicine
- Ross R. Reichard
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Eric. J. Polley
- Department of Quantitative Health Sciences (Biostatistics), Mayo Clinic
- Nilufer Ertekin-Taner
- Department of Neuroscience
- Rosa Rademakers
- Department of Neuroscience
- Michael A. DeTure
- Department of Neuroscience
- Owen A. Ross
- Department of Neuroscience
- Dennis W. Dickson
- Department of Neuroscience
- Jennifer L. Whitwell
- Department of Radiology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-021-23687-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome of multiple etiologies which affects spoken communication. Here, the authors characterized the molecular pathology, biochemistry, genetics and longitudinal neuroimaging of 32 autopsy-confirmed patients with PAOS who were followed over 10 years.
