Nature Communications (Jun 2021)

A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech

  • Keith A. Josephs,
  • Joseph R. Duffy,
  • Heather M. Clark,
  • Rene L. Utianski,
  • Edythe A. Strand,
  • Mary M. Machulda,
  • Hugo Botha,
  • Peter R. Martin,
  • Nha Trang Thu Pham,
  • Julie Stierwalt,
  • Farwa Ali,
  • Marina Buciuc,
  • Matthew Baker,
  • Cristhoper H. Fernandez De Castro,
  • Anthony J. Spychalla,
  • Christopher G. Schwarz,
  • Robert I. Reid,
  • Matthew L. Senjem,
  • Clifford R. Jack,
  • Val J. Lowe,
  • Eileen H. Bigio,
  • Ross R. Reichard,
  • Eric. J. Polley,
  • Nilufer Ertekin-Taner,
  • Rosa Rademakers,
  • Michael A. DeTure,
  • Owen A. Ross,
  • Dennis W. Dickson,
  • Jennifer L. Whitwell

DOI
https://doi.org/10.1038/s41467-021-23687-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome of multiple etiologies which affects spoken communication. Here, the authors characterized the molecular pathology, biochemistry, genetics and longitudinal neuroimaging of 32 autopsy-confirmed patients with PAOS who were followed over 10 years.