LOZENGES FORMULATION OF MIXED EXTRACT OF Curcuma xanthorrhiza Roxb AND Kaempferia galanga L USING COMBINATION OF FILLER AGENTS MANITOL – MALTODEXTRIN

Abstract

Mixture of temulawak and kencur is usually used to increase appetite, but the usual dosage form is less practical and unstable. It is therefore will be better to make it into lozenges, that will be more practical and acceptable. This research aims to determine the effect of filler agent manitol-maltodextrin variations to the physical characteristics of granule, tablet, and the flavor of the tablet. The extracts of temulawak and kencur were made by percolation using ethanol 70%, wet granulated, and made for three formulas of combination manitol-maltodextrin (100:0, 85:15, 70:30). Results showed that the combination of manitol-maltodextrin had affected the time of flow, physical behavior of granule and lozenges compactibility, except for appearance test. The result of flavor test showed respondents stated formula I was sour, and the formula II and III were bitter.

Keywords

• C. xanthorrhiza, K. galanga, bahan pengisi, tablet hisap