Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans

José F. Muñoz; Toni Delorey; Christopher B. Ford; Bi Yu Li; Dawn A. Thompson; Reeta P. Rao; Christina A. Cuomo

doi:10.1038/s41467-019-09599-8

Nature Communications (Apr 2019)

Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans

José F. Muñoz,
Toni Delorey,
Christopher B. Ford,
Bi Yu Li,
Dawn A. Thompson,
Reeta P. Rao,
Christina A. Cuomo

Affiliations

José F. Muñoz: Broad Institute of MIT and Harvard
Toni Delorey: Broad Institute of MIT and Harvard
Christopher B. Ford: Broad Institute of MIT and Harvard
Bi Yu Li: Broad Institute of MIT and Harvard
Dawn A. Thompson: Broad Institute of MIT and Harvard
Reeta P. Rao: Broad Institute of MIT and Harvard
Christina A. Cuomo: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-019-09599-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The outcomes of the interactions between individual host cells and pathogens are heterogeneous. Here, the authors assess transcriptional variability in both host and pathogen during infection of macrophages with the fungus Candida albicans, using sorted subpopulations and single macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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