OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Danna Sheinboim; Itay Maza; Iris Dror; Shivang Parikh; Vladislav Krupalnik; Rachel E. Bell; Asaf Zviran; Yusuke Suita; Ofir Hakim; Yael Mandel-Gutfreund; Mehdi Khaled; Jacob H. Hanna; Carmit Levy

doi:10.1038/s41467-017-01122-1

Nature Communications (Oct 2017)

OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Danna Sheinboim,
Itay Maza,
Iris Dror,
Shivang Parikh,
Vladislav Krupalnik,
Rachel E. Bell,
Asaf Zviran,
Yusuke Suita,
Ofir Hakim,
Yael Mandel-Gutfreund,
Mehdi Khaled,
Jacob H. Hanna,
Carmit Levy

Affiliations

Danna Sheinboim: Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University
Itay Maza: Department of Molecular Genetics, Weizmann Institute of Science
Iris Dror: Department of Biology, Technion–Israel Institute of Technology
Shivang Parikh: Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University
Vladislav Krupalnik: Department of Molecular Genetics, Weizmann Institute of Science
Rachel E. Bell: Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University
Asaf Zviran: Department of Molecular Genetics, Weizmann Institute of Science
Yusuke Suita: Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital
Ofir Hakim: The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan University
Yael Mandel-Gutfreund: Department of Biology, Technion–Israel Institute of Technology
Mehdi Khaled: Institut Gustave Roussy
Jacob H. Hanna: Department of Molecular Genetics, Weizmann Institute of Science
Carmit Levy: Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University

DOI: https://doi.org/10.1038/s41467-017-01122-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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