BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells

Wu Ying; Li Xue-Ying; Chen Jin-Dong; Pan You-Fu

doi:10.1515/biol-2025-1140

Open Life Sciences (Jul 2025)

BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells

Wu Ying,
Li Xue-Ying,
Chen Jin-Dong,
Pan You-Fu

Affiliations

Wu Ying: Department of Medical Genetics, Zunyi Medical University School of Preclinical Medicine, 6 Xuefuxi Rd., Xinpu District, Zunyi, Guizhou, 563003, China
Li Xue-Ying: Department of Medical Genetics, Zunyi Medical University School of Preclinical Medicine, 6 Xuefuxi Rd., Xinpu District, Zunyi, Guizhou, 563003, China
Chen Jin-Dong: Exploring health LLC., Guangzhou, Guangdong, 510663, China
Pan You-Fu: Department of Medical Genetics, Zunyi Medical University School of Preclinical Medicine, 6 Xuefuxi Rd., Xinpu District, Zunyi, Guizhou, 563003, China

DOI: https://doi.org/10.1515/biol-2025-1140
Journal volume & issue: Vol. 20, no. 1
pp. 10 – 45

Abstract

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Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional role of BAP1 in ccRCC, the potential interacting proteins with BAP1 in ccRCC cells are to be identified, and the gene expression profiles of BAP1 knockdown 786-O cells are to be analyzed.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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Abstract

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