Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Ritika Tiwari; Nishat Manzar; Vipul Bhatia; Anjali Yadav; Mushtaq A. Nengroo; Dipak Datta; Shannon Carskadon; Nilesh Gupta; Michael Sigouros; Francesca Khani; Matti Poutanen; Amina Zoubeidi; Himisha Beltran; Nallasivam Palanisamy; Bushra Ateeq

doi:10.1038/s41467-019-14184-0

Nature Communications (Jan 2020)

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Ritika Tiwari,
Nishat Manzar,
Vipul Bhatia,
Anjali Yadav,
Mushtaq A. Nengroo,
Dipak Datta,
Shannon Carskadon,
Nilesh Gupta,
Michael Sigouros,
Francesca Khani,
Matti Poutanen,
Amina Zoubeidi,
Himisha Beltran,
Nallasivam Palanisamy,
Bushra Ateeq

Affiliations

Ritika Tiwari: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Nishat Manzar: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Vipul Bhatia: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Anjali Yadav: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Mushtaq A. Nengroo: Division of Cancer Biology, CSIR-Central Drug Research Institute
Dipak Datta: Division of Cancer Biology, CSIR-Central Drug Research Institute
Shannon Carskadon: Vattikuti Urology Institute, Department of Urology, Henry Ford Health System
Nilesh Gupta: Department of Pathology, Henry Ford Health System
Michael Sigouros: Division of Medical Oncology, Weill Cornell Medicine
Francesca Khani: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Matti Poutanen: Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku
Amina Zoubeidi: Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia
Himisha Beltran: Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School
Nallasivam Palanisamy: Vattikuti Urology Institute, Department of Urology, Henry Ford Health System
Bushra Ateeq: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur

DOI: https://doi.org/10.1038/s41467-019-14184-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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