TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

Jie Jiang; Li Gao; Yongting Lan; Yang Wang; Peiqing Zhao

doi:10.3389/fonc.2020.593615

Frontiers in Oncology (Jan 2021)

TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

Jie Jiang,
Li Gao,
Yongting Lan,
Yang Wang,
Peiqing Zhao

Affiliations

Jie Jiang: Department of Clinical Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China
Li Gao: Department of Stomatology, Zibo Central Hospital, Shandong University, Zibo, China
Yongting Lan: Center of Translational Medicine, Zibo Central Hospital, Shandong University, Zibo, China
Yang Wang: Department of Clinical Laboratory, Huantai County People’s Hospital, Zibo, China
Peiqing Zhao: Center of Translational Medicine, Zibo Central Hospital, Shandong University, Zibo, China

DOI: https://doi.org/10.3389/fonc.2020.593615
Journal volume & issue: Vol. 10

Abstract

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Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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