Nature Communications (Jul 2020)

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

  • Lívia H. Yamashiro,
  • Stephen C. Wilson,
  • Huntly M. Morrison,
  • Vasiliki Karalis,
  • Jing-Yi J. Chung,
  • Katherine J. Chen,
  • Helen S. Bateup,
  • Moriah L. Szpara,
  • Angus Y. Lee,
  • Jeffery S. Cox,
  • Russell E. Vance

DOI
https://doi.org/10.1038/s41467-020-17156-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.