A rare case of primary pulmonary diffuse large B cell lymphoma with CD5 positive expression
Wang Tao,
Zhang Mingming,
Sun Jianrong,
Hao Dong,
Qi Zhijiang,
Lu Feng,
Ji Hong,
Liu Weili,
Wang Xiaozhi,
Wu Dawei
Affiliations
Wang Tao
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China
Zhang Mingming
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China
Sun Jianrong
Department of Hematology, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China
Hao Dong
Department of Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China
Qi Zhijiang
Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
Lu Feng
Department of Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China
Ji Hong
Department of Pathology, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China
Liu Weili
Department of Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China
Wang Xiaozhi
Department of Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, 256603, China. Tel: 13561578530, Fax: 0543-3258595
Wu Dawei
Department of Critical Care Medicine, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan, 250012, China. Tel: 18560081001, Fax: 0531-86927544
Primary pulmonary diffuse large B-cell lymphoma (PPDLBCL) is extremely rare. Its clinical symptoms and signs are nonspe cific, and imaging features also have not yet been well-defined. Further description is important for the diagnosis and treatment of PPDLBCL. Herein, we reported a case of a patient who suffered from bilateral chest pain and dyspnea. Computed tomography (CT) of chest demonstrated bilateral lung mass, consolidations and reverse halo sign, while consolidations and reverse halo sign are uncommon according to previous reports. Tissue samples were taken by CT guided needle biopsy. The histological samples showed PPDLBCL. This case was special in view of positive expression of CD5. After the case was treated by cyclophosphamide pirarubicin vindesine dexamethasone (CHOP) chemotherapy for six courses, her clinical symptoms were partially alleviated, while CT showed progression disease. This case report highlights different imaging features and characteristics of molecular biology, and reviews study progress of PPDLBCL.
