Nature Communications (Jun 2020)
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
- Haruka Toda,
- Miriam Diaz-Varela,
- Joan Segui-Barber,
- Wanlapa Roobsoong,
- Barbara Baro,
- Susana Garcia-Silva,
- Alicia Galiano,
- Melisa Gualdrón-López,
- Anne C. G. Almeida,
- Marcelo A. M. Brito,
- Gisely Cardoso de Melo,
- Iris Aparici-Herraiz,
- Carlos Castro-Cavadía,
- Wuelton Marcelo Monteiro,
- Eva Borràs,
- Eduard Sabidó,
- Igor C. Almeida,
- Jakub Chojnacki,
- Javier Martinez-Picado,
- Maria Calvo,
- Pilar Armengol,
- Jaime Carmona-Fonseca,
- Maria Fernanda Yasnot,
- Ricardo Lauzurica,
- Antonio Marcilla,
- Hector Peinado,
- Mary R. Galinski,
- Marcus V. G. Lacerda,
- Jetsumon Sattabongkot,
- Carmen Fernandez-Becerra,
- Hernando A. del Portillo
Affiliations
- Haruka Toda
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Miriam Diaz-Varela
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Joan Segui-Barber
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Wanlapa Roobsoong
- Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University
- Barbara Baro
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Susana Garcia-Silva
- Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO)
- Alicia Galiano
- Àrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València
- Melisa Gualdrón-López
- Germans Trias i Pujol Health Science Research Institute (IGTP)
- Anne C. G. Almeida
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Marcelo A. M. Brito
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Gisely Cardoso de Melo
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Iris Aparici-Herraiz
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Carlos Castro-Cavadía
- Grupo de Salud y Comunidad Cesar Uribe Piedrahíta, Universidad de Antioquia
- Wuelton Marcelo Monteiro
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Eva Borràs
- Proteomics Unit, Centre de Regulació Genòmica (CRG), Barcelona Institute of Science and Technology (BIST)
- Eduard Sabidó
- Proteomics Unit, Centre de Regulació Genòmica (CRG), Barcelona Institute of Science and Technology (BIST)
- Igor C. Almeida
- Border Biomedical Research Center, Department of Biological Sciences, College of Science, University of Texas El Paso
- Jakub Chojnacki
- AIDS Research Institute IrsiCaixa
- Javier Martinez-Picado
- Germans Trias i Pujol Health Science Research Institute (IGTP)
- Maria Calvo
- Unitat de Microscopia Òptica Avançada, Facultat de Medicina, Centres Científics i Tecnològics, Universitat de Barcelona
- Pilar Armengol
- Germans Trias i Pujol Health Science Research Institute (IGTP)
- Jaime Carmona-Fonseca
- Grupo de Salud y Comunidad Cesar Uribe Piedrahíta, Universidad de Antioquia
- Maria Fernanda Yasnot
- Grupo de Investigaciones Microbiológicas y Biomédicas de Córdoba-GIMBIC, Universidad de Córdoba
- Ricardo Lauzurica
- Nephrology Service, Germans Trias i Pujol University Hospital
- Antonio Marcilla
- Àrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València
- Hector Peinado
- Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO)
- Mary R. Galinski
- Emory Vaccine Center, Yerkes National Primate Research Center, School of Medicine, Division of Infectious Diseases, Emory University
- Marcus V. G. Lacerda
- Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
- Jetsumon Sattabongkot
- Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University
- Carmen Fernandez-Becerra
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- Hernando A. del Portillo
- ISGlobal, Hospital Clínic - Universitat de Barcelona
- DOI
- https://doi.org/10.1038/s41467-020-16337-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.
