Nature Communications (Jun 2018)
Cell entry of a host-targeting protein of oomycetes requires gp96
- Franziska Trusch,
- Lars Loebach,
- Stephan Wawra,
- Elaine Durward,
- Andreas Wuensch,
- Nurul Aqilah Iberahim,
- Irene de Bruijn,
- Kevin MacKenzie,
- Ariane Willems,
- Aleksandra Toloczko,
- Javier Diéguez-Uribeondo,
- Tim Rasmussen,
- Thomas Schrader,
- Peter Bayer,
- Chris J. Secombes,
- Pieter van West
Affiliations
- Franziska Trusch
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Lars Loebach
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Stephan Wawra
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Elaine Durward
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Andreas Wuensch
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Nurul Aqilah Iberahim
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Irene de Bruijn
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Kevin MacKenzie
- Microscopy and Histology Facility, Institute of Medical Sciences, University of Aberdeen
- Ariane Willems
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Aleksandra Toloczko
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- Javier Diéguez-Uribeondo
- Department of Mycology, Real Jardín Botánico CSIC
- Tim Rasmussen
- Institute of Medical Sciences, University of Aberdeen
- Thomas Schrader
- Organic Chemistry, University of Duisburg-Essen
- Peter Bayer
- Structural and Medicinal Biochemistry, Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen
- Chris J. Secombes
- International Centre for Aquaculture Research and Development (ICARD), University of Aberdeen
- Pieter van West
- Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen
- DOI
- https://doi.org/10.1038/s41467-018-04796-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The pathogenic oomycete Saprolegnia parasitica secretes effector proteins that translocate into host cells through unclear mechanisms. Here, Trusch et al. show that the uptake of effector protein SpHtp3, resulting in RNA degradation, depends on a gp96-like host receptor and a second effector protein.
