Nature Communications (Jun 2018)

Cell entry of a host-targeting protein of oomycetes requires gp96

  • Franziska Trusch,
  • Lars Loebach,
  • Stephan Wawra,
  • Elaine Durward,
  • Andreas Wuensch,
  • Nurul Aqilah Iberahim,
  • Irene de Bruijn,
  • Kevin MacKenzie,
  • Ariane Willems,
  • Aleksandra Toloczko,
  • Javier Diéguez-Uribeondo,
  • Tim Rasmussen,
  • Thomas Schrader,
  • Peter Bayer,
  • Chris J. Secombes,
  • Pieter van West

DOI
https://doi.org/10.1038/s41467-018-04796-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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The pathogenic oomycete Saprolegnia parasitica secretes effector proteins that translocate into host cells through unclear mechanisms. Here, Trusch et al. show that the uptake of effector protein SpHtp3, resulting in RNA degradation, depends on a gp96-like host receptor and a second effector protein.