Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis

Yi-Yu Chen; Jing-Yu Ge; Si-Yuan Zhu; Zhi-Ming Shao; Ke-Da Yu

doi:10.1038/s41467-022-28452-z

Nature Communications (Feb 2022)

Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis

Yi-Yu Chen,
Jing-Yu Ge,
Si-Yuan Zhu,
Zhi-Ming Shao,
Ke-Da Yu

Affiliations

Yi-Yu Chen: Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute, Shanghai Medical College, Fudan University
Jing-Yu Ge: Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute, Shanghai Medical College, Fudan University
Si-Yuan Zhu: Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute, Shanghai Medical College, Fudan University
Zhi-Ming Shao: Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute, Shanghai Medical College, Fudan University
Ke-Da Yu: Department of Breast Surgery, Shanghai Cancer Center and Cancer Institute, Shanghai Medical College, Fudan University

DOI: https://doi.org/10.1038/s41467-022-28452-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Copy number alterations are pivotal genetic events in triple-negative breast cancer. Here the authors show the amplification of ENSA at the 1q21.3 region promotes the progression of TNBC via up-regulation of cholesterol biosynthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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