USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

Achuth Padmanabhan; Nicholes Candelaria; Kwong-Kwok Wong; Bryan C. Nikolai; David M. Lonard; Bert W. O’Malley; JoAnne S. Richards

doi:10.1038/s41467-018-03599-w

Nature Communications (Mar 2018)

USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

Achuth Padmanabhan,
Nicholes Candelaria,
Kwong-Kwok Wong,
Bryan C. Nikolai,
David M. Lonard,
Bert W. O’Malley,
JoAnne S. Richards

Affiliations

Achuth Padmanabhan: Department of Molecular and Cellular Biology, Baylor College of Medicine
Nicholes Candelaria: Department of Molecular and Cellular Biology, Baylor College of Medicine
Kwong-Kwok Wong: Department of Gynecologic Oncology and Reproductive Medicine - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center
Bryan C. Nikolai: Department of Molecular and Cellular Biology, Baylor College of Medicine
David M. Lonard: Department of Molecular and Cellular Biology, Baylor College of Medicine
Bert W. O’Malley: Department of Molecular and Cellular Biology, Baylor College of Medicine
JoAnne S. Richards: Department of Molecular and Cellular Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-018-03599-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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