Nature Communications (Jan 2021)

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

  • Daniel Grau,
  • Yixiao Zhang,
  • Chul-Hwan Lee,
  • Marco Valencia-Sánchez,
  • Jenny Zhang,
  • Miao Wang,
  • Marlene Holder,
  • Vladimir Svetlov,
  • Dongyan Tan,
  • Evgeny Nudler,
  • Danny Reinberg,
  • Thomas Walz,
  • Karim-Jean Armache

DOI
https://doi.org/10.1038/s41467-020-20775-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational changes during the process.