Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery

Abstract

Ardeshir Khazaei1, Mohammad Navid Soltani Rad2, Maryam Kiani Borazjani11Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran; 2Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz, IranAbstract: The grafting of drugs to the single-walled carbon nanotube (SWCNT) was attained by the initial conversion of carboxylic groups in SWCNT to corresponding acyl chlorides. The active acyl chlorides in SWCNT were subsequently mixed with chemotherapeutic agents having NH, NH2, and OH functional groups to afford the formation of relevant amide and ester, respectively. The covalently grafted drugs to SWCNT were identified by infrared and UV–visible spectroscopy and transmission electron microscopy methods. From a clinical aspect, the grafting of drugs to the SWCNT can be used as a new tool and useful method for potential drug delivery in patients.Keywords: grafting of drugs, solubilization