TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

Ei’ichi Iizasa; Yasushi Chuma; Takayuki Uematsu; Mio Kubota; Hiroaki Kawaguchi; Masayuki Umemura; Kenji Toyonaga; Hideyasu Kiyohara; Ikuya Yano; Marco Colonna; Masahiko Sugita; Goro Matsuzaki; Sho Yamasaki; Hiroki Yoshida; Hiromitsu Hara

doi:10.1038/s41467-021-22620-3

Nature Communications (Apr 2021)

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

Ei’ichi Iizasa,
Yasushi Chuma,
Takayuki Uematsu,
Mio Kubota,
Hiroaki Kawaguchi,
Masayuki Umemura,
Kenji Toyonaga,
Hideyasu Kiyohara,
Ikuya Yano,
Marco Colonna,
Masahiko Sugita,
Goro Matsuzaki,
Sho Yamasaki,
Hiroki Yoshida,
Hiromitsu Hara

Affiliations

Ei’ichi Iizasa: Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University
Yasushi Chuma: Research and Development Department, Japan BCG Laboratory
Takayuki Uematsu: Biomedical Laboratory, Division of Biomedical Research, Kitasato University Medical Center
Mio Kubota: Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University
Hiroaki Kawaguchi: Department of Hygiene and Health Promotion Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University
Masayuki Umemura: Tropical Biosphere Research Center, University of the Ryukyus
Kenji Toyonaga: Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University
Hideyasu Kiyohara: Research and Development Department, Japan BCG Laboratory
Ikuya Yano: Research and Development Department, Japan BCG Laboratory
Marco Colonna: Department of Pathology and Immunology, BJC Institute of Health at Washington University
Masahiko Sugita: Laboratory of Cell Regulation, Institute for Virus Research, Graduate School of Biostudies, Kyoto University
Goro Matsuzaki: Tropical Biosphere Research Center, University of the Ryukyus
Sho Yamasaki: Department of Molecular Immunology, Division of Host Defense, Research Institute for Microbial Disease, Osaka University
Hiroki Yoshida: Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University
Hiromitsu Hara: Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University

DOI: https://doi.org/10.1038/s41467-021-22620-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Mycobacterial cell wall lipids can drive immunoevasion, but underlying mechanisms are incompletely understood. Here the authors show TREM2 is a pattern recognition receptor that binds non-glycosylated mycolic acid-containing lipids and inhibits Mincle-induced anti-mycobacterial macrophage responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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