Фармакокинетика и Фармакодинамика (Mar 2017)

The effects of levetiracetam and a new 4-phenylpyrrolidone derivative GIZh-290 in a closed cross-maze in BALB/c and C57BL / 6 mice

  • I. G. Kovalev,
  • E. V. Vasileva,
  • R. O. Bokov,
  • R. M. Salimov,
  • G. I. Kovalev

Journal volume & issue
Vol. 0, no. 2
pp. 25 – 29

Abstract

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The study was aimed to compare the psychopharmacological effects of 2 anticonvulsant drugs levetiracetam ((S)-2-(2-oxopyrrolidin-1-yl) butanamide) and the new compound, GIZh-290 (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid) on behavioral spectra of inbred mice BALB/c and C57BL/6 under conditions of "closed cross-maze" test. It was found that after 5-fold i.p. injections levetiracetam (600 mg/kg/day) reduced the cognitive and motor ability of C57BL/6 mice, while in BALB/c mice the drug increased anxiety and diminished motor activity. In contrast, the substance GIZh-290 (5 mg/kg/day, i.p.) had no effect in C57BL/6. Compound GIZh-290 (5 mg/kg/day, 5 days, ip) does not affect the behavior of C57BL/6 mice, but depressed the motor activity in BALB/c mice.

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