Nature Communications (Jul 2018)
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
- Sandhya Bangaru,
- Heng Zhang,
- Iuliia M. Gilchuk,
- Thomas G. Voss,
- Ryan P. Irving,
- Pavlo Gilchuk,
- Pranathi Matta,
- Xueyong Zhu,
- Shanshan Lang,
- Travis Nieusma,
- Juergen A. Richt,
- Randy A. Albrecht,
- Hillary A. Vanderven,
- Robin Bombardi,
- Stephen J. Kent,
- Andrew B. Ward,
- Ian A. Wilson,
- James E. Crowe
Affiliations
- Sandhya Bangaru
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- Heng Zhang
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Iuliia M. Gilchuk
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Thomas G. Voss
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Ryan P. Irving
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Pavlo Gilchuk
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Pranathi Matta
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Xueyong Zhu
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Shanshan Lang
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Travis Nieusma
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Juergen A. Richt
- College of Veterinary Medicine, Kansas State University
- Randy A. Albrecht
- Department of Microbiology, Global Health and Emerging Pathogens Institute, at Icahn School of Medicine at Mount Sina
- Hillary A. Vanderven
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Robin Bombardi
- The Vanderbilt Vaccine Center, Vanderbilt University Medical Center
- Stephen J. Kent
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Andrew B. Ward
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Ian A. Wilson
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- James E. Crowe
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-04704-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease.
