Influence of acidic metabolic environment on differentiation of stem cell-derived cardiomyocytes

Mao Jiahao; Zhou Fan; Mu Junsheng

doi:10.3389/fcvm.2024.1288710

Frontiers in Cardiovascular Medicine (Mar 2024)

Influence of acidic metabolic environment on differentiation of stem cell-derived cardiomyocytes

Mao Jiahao,
Zhou Fan,
Mu Junsheng

Affiliations

Mao Jiahao: Department of Cardiac Surgery, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Zhou Fan: Department of Ultrasound, The Third Medical Center of PLA General Hospital, Beijing, China
Mu Junsheng: Department of Cardiac Surgery, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

DOI: https://doi.org/10.3389/fcvm.2024.1288710
Journal volume & issue: Vol. 11

Abstract

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Stem cell-based myocardial regeneration is a frontier topic in the treatment of myocardial infarction. Manipulating the metabolic microenvironment of stem cells can influence their differentiation into cardiomyocytes, which have promising clinical applications. pH is an important indicator of the metabolic environment during cardiomyocyte development. And lactate, as one of the main acidic metabolites, is a major regulator of the acidic metabolic environment during early cardiomyocyte development. Here, we summarize the progress of research into the influence of pH value and lactate on cardiomyocyte survival and differentiation, as well as related mechanisms.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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