Nature Communications (Oct 2021)
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors
- Wei Xia,
- Jing Xie,
- Zhiqing Cai,
- Xuhua Liu,
- Jing Wen,
- Zhong-Kai Cui,
- Run Zhao,
- Xiaomei Zhou,
- Jiahui Chen,
- Xinru Mao,
- Zhengtao Gu,
- Zhimin Zou,
- Zhipeng Zou,
- Yue Zhang,
- Ming Zhao,
- Maegele Mac,
- Qiancheng Song,
- Xiaochun Bai
Affiliations
- Wei Xia
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Jing Xie
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Zhiqing Cai
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Xuhua Liu
- State Key Laboratory of Organ Failure Research, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital of Southern Medical University
- Jing Wen
- Department of Radiology, Nanfang Hospital, Southern Medical University
- Zhong-Kai Cui
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Run Zhao
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Xiaomei Zhou
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Jiahui Chen
- State Key Laboratory of Organ Failure Research, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital of Southern Medical University
- Xinru Mao
- Department of Clinical laboratory, Nanfang Hospital, Southern Medical University
- Zhengtao Gu
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University
- Zhimin Zou
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University
- Zhipeng Zou
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Yue Zhang
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Ming Zhao
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University
- Maegele Mac
- Institute for Research in Operative Medicine, Private University of Witten-Herdecke, Cologne Merheim Medical Center
- Qiancheng Song
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- Xiaochun Bai
- Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University
- DOI
- https://doi.org/10.1038/s41467-021-26302-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Concomitant traumatic brain injury accelerates bone healing, but the mechanism is unclear. Here, the authors show that injured neurons, mainly those in the hippocampus, release osteogenic miRNA-enriched small extracellular vesicles, which targete osteoprogenitors to stimulate bone formation.
