Comparison of the Anesthetic Effects of Different Doses of Ketamine Hydrochloride Combined Xylazine on Short-term Anesthesia in Bama Miniature Pigs

Abstract

Objectives To perform the combined anesthesia of ketamine hydrochloride and xylazine in miniature pigs, and to analyze the effect of drug dose on anesthesia.Methods Thirty-six Bama miniature pigs were randomly divided into three groups. Group A was administered with ketamine hydrochloride (10 mg/kg) + xylazine (2 mg/kg). Group B was administered with ketamine hydrochloride (10 mg/kg) + xylazine (1.5 mg/kg). Group C was administered with ketamine hydrochloride (5 mg/kg) + xylazine (2 mg/kg), and anesthesia monitoring indexes were recorded.Results There were no significant differences in anesthesia onset time and awake time between groups A and B (P > 0.05), and the awake time of anesthesia in groups A and B was significantly longer than that in group C (P < 0.05).Conclusion Ketamine hydrochloride (10 mg/kg) combined with xylazine (1.5‒2 mg/kg) anesthesia has a rapid effect, stable anesthesia depth, no obvious movement, and satisfactory safety. It can be used in short procedures, diagnoses, and treatments.

Keywords

• ketamine hydrochloride
• xylazine
• bama miniature pig
• combined anesthesia