Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage

Xiurong Zhao; Shun-Ming Ting; Chin-Hsuan Liu; Guanghua Sun; Marian Kruzel; Meaghan Roy-O’Reilly; Jaroslaw Aronowski

doi:10.1038/s41467-017-00770-7

Nature Communications (Sep 2017)

Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage

Xiurong Zhao,
Shun-Ming Ting,
Chin-Hsuan Liu,
Guanghua Sun,
Marian Kruzel,
Meaghan Roy-O’Reilly,
Jaroslaw Aronowski

Affiliations

Xiurong Zhao: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School
Shun-Ming Ting: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School
Chin-Hsuan Liu: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School
Guanghua Sun: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School
Marian Kruzel: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, McGovern Medical School
Meaghan Roy-O’Reilly: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School
Jaroslaw Aronowski: Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School

DOI: https://doi.org/10.1038/s41467-017-00770-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Neutrophils are important modulators of tissue damage after intracerebral hemorrhage (ICH), but how this function is regulated is not clear. Here, the authors show interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin to present a potential therapy for ICH.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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