Nature Communications (Jul 2021)
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
- Allison J. Greaney,
- Tyler N. Starr,
- Christopher O. Barnes,
- Yiska Weisblum,
- Fabian Schmidt,
- Marina Caskey,
- Christian Gaebler,
- Alice Cho,
- Marianna Agudelo,
- Shlomo Finkin,
- Zijun Wang,
- Daniel Poston,
- Frauke Muecksch,
- Theodora Hatziioannou,
- Paul D. Bieniasz,
- Davide F. Robbiani,
- Michel C. Nussenzweig,
- Pamela J. Bjorkman,
- Jesse D. Bloom
Affiliations
- Allison J. Greaney
- Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center
- Tyler N. Starr
- Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center
- Christopher O. Barnes
- Division of Biology and Biological Engineering, California Institute of Technology
- Yiska Weisblum
- Laboratory of Retrovirology, The Rockefeller University
- Fabian Schmidt
- Laboratory of Retrovirology, The Rockefeller University
- Marina Caskey
- Laboratory of Molecular Immunology, The Rockefeller University
- Christian Gaebler
- Laboratory of Molecular Immunology, The Rockefeller University
- Alice Cho
- Laboratory of Molecular Immunology, The Rockefeller University
- Marianna Agudelo
- Laboratory of Molecular Immunology, The Rockefeller University
- Shlomo Finkin
- Laboratory of Molecular Immunology, The Rockefeller University
- Zijun Wang
- Laboratory of Molecular Immunology, The Rockefeller University
- Daniel Poston
- Laboratory of Retrovirology, The Rockefeller University
- Frauke Muecksch
- Laboratory of Retrovirology, The Rockefeller University
- Theodora Hatziioannou
- Laboratory of Retrovirology, The Rockefeller University
- Paul D. Bieniasz
- Howard Hughes Medical Institute
- Davide F. Robbiani
- Laboratory of Molecular Immunology, The Rockefeller University
- Michel C. Nussenzweig
- Howard Hughes Medical Institute
- Pamela J. Bjorkman
- Division of Biology and Biological Engineering, California Institute of Technology
- Jesse D. Bloom
- Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-021-24435-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas.
