Targeted Prostate Biopsy Using 68Gallium PSMA-PET/CT for Image Guidance

Demetrios N. Simopoulos; Shyam Natarajan; Tonye A. Jones; Wolfgang P. Fendler; Anthony E. Sisk, Jr.; Leonard S. Marks

doi:10.1016/j.eucr.2017.05.006

Urology Case Reports (Sep 2017)

Targeted Prostate Biopsy Using 68Gallium PSMA-PET/CT for Image Guidance

Demetrios N. Simopoulos,
Shyam Natarajan,
Tonye A. Jones,
Wolfgang P. Fendler,
Anthony E. Sisk, Jr.,
Leonard S. Marks

Affiliations

Demetrios N. Simopoulos: Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, 300 Stein Plaza, 3rd Floor, Los Angeles, CA 90095, USA
Shyam Natarajan: Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, 300 Stein Plaza, 3rd Floor, Los Angeles, CA 90095, USA
Tonye A. Jones: Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, 300 Stein Plaza, 3rd Floor, Los Angeles, CA 90095, USA
Wolfgang P. Fendler: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, 10833 Le Conte Avenue, 200 Medical Plaza, Suite B114-61, Los Angeles, CA 90095, USA
Anthony E. Sisk, Jr.: Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, 10833 LeConte Avenue, A3-240 CHS, Los Angeles, CA 90095, USA
Leonard S. Marks: Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, 300 Stein Plaza, 3rd Floor, Los Angeles, CA 90095, USA

DOI: https://doi.org/10.1016/j.eucr.2017.05.006
Journal volume & issue: Vol. 14, no. C
pp. 11 – 14

Abstract

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Prostate specific membrane antigen (PSMA) scanning is a sensitive method of prostate cancer detection. In a 71 y.o. man with a PSA of 49 (6%F), 4 negative MRI studies and 6 negative biopsies over an 8 year interval, a 68Ga-PSMA PET/CT scan showed a PSMA-avid spot in the prostate. Using image fusion technology, the lesion was target-biopsied and Gleason 3 + 4 = 7 (cancer core length of 12 mm) was identified. This case may herald a new application for PSMA scanning and prostate cancer imaging.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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Abstract

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