Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

Seok-Ting J. Ang; Elisa M. Crombie; Han Dong; Kuan-Ting Tan; Adriel Hernando; Dejie Yu; Stuart Adamson; Seonyoung Kim; Dominic J. Withers; Hua Huang; Shih-Yin Tsai

doi:10.1038/s41467-022-35547-0

Nature Communications (Dec 2022)

Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

Seok-Ting J. Ang,
Elisa M. Crombie,
Han Dong,
Kuan-Ting Tan,
Adriel Hernando,
Dejie Yu,
Stuart Adamson,
Seonyoung Kim,
Dominic J. Withers,
Hua Huang,
Shih-Yin Tsai

Affiliations

Seok-Ting J. Ang: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Elisa M. Crombie: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Han Dong: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Kuan-Ting Tan: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Adriel Hernando: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Dejie Yu: Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
Stuart Adamson: Buck Institute for Research on Aging
Seonyoung Kim: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
Dominic J. Withers: Metabolic Signalling Group, Medical Research Council Clinical Council London Institute of Medical Sciences (LMS)
Hua Huang: Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
Shih-Yin Tsai: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-35547-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP1 in the muscle remodeled the neuromuscular junction and enhanced synaptic transmission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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