Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies

Gijs D. van Praagh; Pieter H. Nienhuis; Daniel M. de Jong; Melanie Reijrink; Kornelis S. M. van der Geest; Elisabeth Brouwer; Andor W. J. M. Glaudemans; Bhanu Sinha; Antoon T. M. Willemsen; Riemer H. J. A. Slart

doi:10.3390/diagnostics11111986

Diagnostics (Oct 2021)

Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies

Gijs D. van Praagh,
Pieter H. Nienhuis,
Daniel M. de Jong,
Melanie Reijrink,
Kornelis S. M. van der Geest,
Elisabeth Brouwer,
Andor W. J. M. Glaudemans,
Bhanu Sinha,
Antoon T. M. Willemsen,
Riemer H. J. A. Slart

Affiliations

Gijs D. van Praagh: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Pieter H. Nienhuis: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Daniel M. de Jong: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Melanie Reijrink: Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Kornelis S. M. van der Geest: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Elisabeth Brouwer: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Andor W. J. M. Glaudemans: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Bhanu Sinha: Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
Antoon T. M. Willemsen: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Riemer H. J. A. Slart: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands

DOI: https://doi.org/10.3390/diagnostics11111986
Journal volume & issue: Vol. 11, no. 11
p. 1986

Abstract

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The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all p p > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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